CJC-1295 DAC

CJC-1295 DAC is described as a GHRH (Growth Hormone Releasing Hormone) analog that increases the creation and release of growth hormone. It’s presented as a modified version of MOD-GRF 1-29; the DAC (drug affinity complex) modification is noted for extending activity/half-life into the ~6–8 day range (rather than minutes).

Dosing & Cycling:
Note: The source notes that daily injections can push GH levels above normal physiological ranges.

Timing / Food Note:
• The source notes carbohydrates and fatty acids may blunt growth hormone release.
• Common timing guidance listed: 30 minutes before eating and/or 2 hours after eating.

Combination Note (Research Context):
• CJC-1295 is often paired with a GHRP because GHRPs are described as inhibiting somatostatin (which can block GH release).
• The source lists examples such as Ipamorelin, GHRP-2, GHRP-6, or Hexarelin for synergy.

Caution & Contraindications:
Cautions: May cause water retention, hunger, headaches, changes in blood sugar levels, and/or joint pain.
• Use caution in individuals with existing hormonal imbalances or related conditions.
• Extended use or higher doses may cause over-saturation of receptors.
Contraindications: Individuals with active or a history of hormone-sensitive cancers.

Reconstitution Options (Vial Formats):
• 2 mg
• 5 mg
• 10 mg

Reconstitution (General Handling):
• Use sterile technique and sanitize the vial stopper before access.
• Add bacteriostatic water slowly along the vial wall to minimize foaming.
• Gently swirl/roll until fully dissolved (avoid vigorous shaking).
• Store refrigerated at 2–8 °C, protected from light, and follow your product’s label/spec sheet for stability guidance.

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

PubChem CID: 56841945

Animal studies show that a single dose of CJC-1295 DAC can elevate GH levels two- to ten-fold, peaking roughly two hours post-administration and remaining elevated for up to six days. Importantly, the analogue preserves the natural pulsatile release of GH and downstream IGF-1.

In models with impaired GHRH physiology, CJC-1295 supports normal GH rhythms, pointing to potential roles in addressing growth deficits or dysregulated endocrine axes.

Historical research suggests that GHRH analogues can influence reproductive hormones. In female subjects, exogenous GH secretagogues have been shown to support ovulatory cycles, likely by boosting IGF-1 alongside GH. Early investigations also speculate on applications in male infertility through potential modulation of spermatogenesis, though dedicated studies are still needed.

CJC-1295 DAC is engineered for prolonged GH release without disrupting natural hormone rhythms. Moderate side effects and excellent subcutaneous bioavailability in murine models make it an attractive research peptide for endocrine, metabolic, and reproductive studies. As always, murine dose data do not translate directly to humans; the peptide remains restricted to licensed research use.

PubMed

Article Author :

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from https://case.edu/medicine/Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Case Western Reserve University School of Medicine

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