Chonluten

Chonluten (Glu–Asp–Gly) is a short bioregulatory tripeptide discussed in the context of bronchopulmonary tissue research and inflammatory signaling in monocyte/macrophage models. Because short peptides like this are described as having poor oral stability, the referenced protocol uses a once-daily subcutaneous approach. Educational context only.

Reconstitution Target (20 mg vial): Add 3.0 mL bacteriostatic water → 6.67 mg/mL.
Easy Measuring (U-100): 1 unit = 0.01 mL ≈ 66.67 mcg.

Dosing Schedule (3.0 mL → 6.67 mg/mL):
Route & Frequency: Inject once daily via the subcutaneous route. Rotate sites for comfort/consistency. For ≤10 unit (≤0.10 mL) administrations during Weeks 1–4, consider 30- or 50-unit insulin syringes for improved readability.

Reconstitution Steps:
• Draw 3.0 mL bacteriostatic water with a sterile syringe.
• Inject slowly down the vial wall to minimize foaming.
• Gently swirl/roll until dissolved (do not shake).
• Label and refrigerate at 2–8 °C, protected from light.
• Avoid repeated freeze–thaw cycles.

Storage (as described):
• Lyophilized (short-term): Refrigerate ~4 °C (dry, dark).
• Lyophilized (long-term): Freeze at −20 °C (or colder).
• Reconstituted: Refrigerate at 2–8 °C; avoid freeze–thaw. Allow vial to reach room temperature before opening to reduce condensation.

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Sequence: Glu-Asp-Gly (EDG)

Molecular Formula: C11H17N3O8

Molecular Weight: 319.27 g/mol

PubChem CID: 194641

CAS Number: 75007-24-8

Synonyms: T-34 tripeptide, EDG

Short peptides—including di-, tri-, and tetrapeptides—have been shown in animal studies to extend lifespan by up to 40% and suppress tumor development. Computational and laboratory data indicate that these peptides can cross nuclear membranes and bind promoter regions to regulate DNA transcription.

Work by Dr. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology highlights Chonluten’s ability to normalize gene expression patterns associated with aging, lending support to its classification as a geroprotective molecule.

Chonluten modulates genes such as c-Fos, HSP70, SOD, COX-2, and TNF-α to normalize bronchial mucosal function. These actions may counteract the structural and inflammatory changes observed in asthma and COPD, restoring mucus balance and extracellular matrix integrity.

Its stress-protective effects and ability to maintain performance in hypoxic conditions have also spurred interest in supportive roles during respiratory infections, including COVID-19 scenarios.

Preliminary research suggests Chonluten exerts similar, albeit milder, regulatory effects in the gastrointestinal tract. Investigations are underway to determine whether its anti-inflammatory gene modulation can translate to benefits in Crohn’s disease, ulcerative colitis, and other GI inflammatory disorders.

Chonluten is a short peptide that modulates genes tied to inflammation, antioxidant defense, and cellular proliferation—particularly in lung tissue. Its geroprotective profile, minimal reported side effects, and favorable subcutaneous bioavailability in mice make it a compelling candidate for further respiratory and anti-aging research.

PubMed

Article Author :

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from https://case.edu/medicine/Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Case Western Reserve University School of Medicine

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